Journal
TRENDS IN CELL BIOLOGY
Volume 21, Issue 3, Pages 177-187Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.11.001
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Funding
- National Institutes of Health (NIH) [RO1 GM079265]
- University of Vermont
- American Heart Association [0835236N]
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How the actin cytoskeleton assembles into different structures to drive diverse cellular processes is a fundamental cell biological question. In addition to orchestrating the appropriate combination of regulators and actin-binding proteins, different actin-based structures must insulate themselves from one another to maintain specificity within a crowded cytoplasm. Actin specification is particularly challenging in complex eukaryotes where a multitude of protein isoforms and actin structures operate within the same cell. Fission yeast Schizosaccharomyces pombe possesses a single actin isoform that functions in three distinct structures throughout the cell cycle. In this review we explore recent studies in fission yeast that help unravel how different actin structures operate in cells.
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