Journal
TRENDS IN CELL BIOLOGY
Volume 21, Issue 2, Pages 122-131Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.10.003
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Funding
- National Institutes of Health [R01GM074876, R01GM087455]
- National Center for Research Resources [P20 RR018759]
- Nebraska Department of Health
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Regulation of endocytic transport is controlled by an elaborate network of proteins. Rab GTP-binding proteins and their effectors have well-defined roles in mediating specific endocytic transport steps, but until recently less was known about the four mammalian dynamin-like C-terminal Eps15 homology domain (EHD) proteins that also regulate endocytic events. In recent years, however, great strides have been made in understanding the structure and function of these unique proteins. Indeed, a growing body of literature addresses EHD protein structure, interactions with binding partners, functions in mammalian cells, and the generation of various new model systems. Accordingly, this is now an opportune time to pause and review the function and mechanisms of action of EHD proteins, and to highlight some of the challenges and future directions for the field.
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