Journal
TRENDS IN CELL BIOLOGY
Volume 21, Issue 6, Pages 336-343Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2011.03.003
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Funding
- National Institutes of Health [GM049369, GM052872]
- Natural Science Foundation of China [B06018]
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Alternative splicing is a process to differentially link exon regions in a single precursor mRNA to produce two or more different mature mRNAs, a strategy frequently used by higher eukaryotic cells to increase proteome diversity and/or enable additional post-transcriptional control of gene expression. This process can take place either co-transcriptionally or post-transcriptionally. When and where RNA splicing takes place in the cell represents a central question of cell biology; co-transcriptional splicing allows functional integration of transcription and RNA processing machineries, and could allow them to modulate one another, whereas post-transcriptional splicing could facilitate coupling RNA splicing with downstream events such as RNA export to create additional layers for regulated gene expression. This review focuses on recent advances in co- and post-transcriptional RNA splicing and proposes a new paradigm that some specific coupling events contribute to genome organization in higher eukaryotic cells.
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