Journal
TRENDS IN CELL BIOLOGY
Volume 21, Issue 6, Pages 321-327Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2011.02.001
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Funding
- NIGMS NIH HHS [R01 GM088252] Funding Source: Medline
- Grants-in-Aid for Scientific Research [21228003, 23370093] Funding Source: KAKEN
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X-chromosome inactivation has long served as an experimental model system for understanding the epigenetic regulation of gene expression. Central to this phenomenon is the long, non-coding RNA Xist that is specifically expressed from the inactive X chromosome and spreads along the entire length of the chromosome in cis. Recently, two of the proteins originally identified as components of the nuclear scaffold/matrix (S/MAR-associated proteins) have been shown to control the principal features of X-chromosome inactivation; specifically, context-dependent competency and the chromosome-wide association of Xist RNA. These findings implicate the involvement of nuclear S/MAR-associated proteins in the organization of epigenetic machinery. Here, we describe a model for the functional role of S/MAR-associated proteins in the regulation of key epigenetic processes.
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