Journal
TRENDS IN CELL BIOLOGY
Volume 20, Issue 7, Pages 410-417Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.04.005
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Funding
- HHMI
- NIH [GM078620, 1F32GM079817]
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The Hippo signaling pathway is a key regulator of growth during animal development, whereas loss of normal Hippo pathway activity is associated with a wide range of cancers. Hippo signaling represses growth by inhibiting the activity of a transcriptional co-activator protein, known as Yorkie in Drosophila and Yap in vertebrates. In the 5 years since the first report linking Yorkie to Hippo signaling, intense interest in this pathway has led to rapid increases in our understanding of the action and regulation of Yorkie/Yap, which we review here. These studies have also emphasized the complexity of Yorkie/Yap regulation, including multiple, distinct mechanisms for repressing its transcriptional activity, and multiple DNA-binding partner proteins that can direct Yorkie to distinct downstream target genes.
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