Journal
TRENDS IN CELL BIOLOGY
Volume 20, Issue 7, Pages 371-379Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.04.001
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Funding
- Austrian Science Fund (FWF) [F 3005] Funding Source: researchfish
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Biological membranes with cubic morphology are a hallmark of stressed or diseased cellular conditions; both protein protein interactions and lipid alterations appear to contribute to their biogenesis, yet their specific cellular functions are unknown. The occurrence of cubic membranes strikingly correlates with viral infections; notably, virus entry, proliferation, and release are processes closely linked to cellular cholesterol metabolism, and dys-regulation of cholesterol synthesis at the level of HMG-CoA reductase also induces cubic membrane formation, in the absence of viral infection. We propose that virus-induced cubic membranes could result from viral interference of cellular cholesterol homeostasis, generating a protective membrane environment to facilitate virus assembly and proliferation. Preventing cubic membrane formation might thus disrupt the 'virus factory' and offer new avenues to combat viral infections.
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