Journal
TRENDS IN CELL BIOLOGY
Volume 20, Issue 12, Pages 715-722Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.09.012
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Funding
- MRC Wellcome Trust
- Department of Health via the NIHR comprehensive Biomedical Research Centre
- UK Stem Cell Foundation
- Medical Research Council [G0600041] Funding Source: researchfish
- MRC [G0600041] Funding Source: UKRI
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Teeth exhibit limited repair in response to damage, and dental pulp stem cells probably provide a source of cells to replace those damaged and to facilitate repair Stem cells in other parts of the tooth, such as the periodontal ligament and growing roots, play more dynamic roles in tooth function and development Dental stem cells can be obtained with ease, making them an attractive source of autologous stem cells for use in restoring vital pulp tissue removed because of infection, in regeneration of periodontal ligament lost in periodontal disease, and for generation of complete or partial tooth structures to form biological implants As dental stem cells share properties with mesenchymal stem cells there is also considerable interest in their wider potential to treat disorders involving mesenchymal (or indeed non-mesenchymal) cell derivatives, such as in Parkinson's disease
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