Journal
TRENDS IN CELL BIOLOGY
Volume 20, Issue 12, Pages 705-714Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2010.09.007
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Funding
- National Institutes of Health [EB00262, EB08396, HL73305, HL90747, GM74048]
- RESBIO Technology Resource for Polymeric Biomaterials
- Center for Engineering Cells and Regeneration of the University of Pennsylvania
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Cells constantly probe and respond to a myriad of cues that are present in their local surroundings The effects of soluble cues are relatively straightforward to manipulate, yet teasing apart how cells transduce signals from the extracellular matrix and neighboring cells has proven to be challenging due to the spatially and mechanically complex adhesive interactions Over the years advances in the engineering of biocompatible materials have enabled innovative ways to study adhesion-mediated cell functions, and numerous insights have elucidated the significance of the cellular microenvironment Here, we highlight some of the major approaches and discuss the potential for future advancement
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