Journal
TRENDS IN CELL BIOLOGY
Volume 20, Issue 1, Pages 25-35Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.09.009
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Funding
- National Institutes of Health [R01 GM051968, F32 GM082005]
- AHA fellowship [0920072G]
- NATIONAL CANCER INSTITUTE [R01CA104708] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM114386, R01GM051968, F32GM082005] Funding Source: NIH RePORTER
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While the presence of phosphoinositides in the nuclei of eukaryotes and the identity of the enzymes responsible for their metabolism have been known for some time, their functions in the nucleus are only now emerging. This is illustrated by the recent identification of effectors for nuclear phosphoinositides. Like the cytosolic phosphoinositide signaling pathway, nuclear phosphatidylinositol 4,5-bisphosphate (PI4,5P(2)) is at the center of the pathway and acts both as a messenger and as a precursor for many additional messengers. Here, recent advances in the understanding of nuclear phosphoinositide signaling and its functions are reviewed with an emphasis on PI4,5P(2) and its role in gene expression. The compartmentalization of nuclear phosphoinositide phosphates (PIPn) remains a mystery, but emerging evidence suggests that phosphoinositides occupy several functionally distinct compartments.
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