Journal
TRENDS IN CELL BIOLOGY
Volume 20, Issue 3, Pages 150-159Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.12.006
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Funding
- Swedish Research Council
- Swedish and the Stockholm Cancer Societies
- Swedish Childhood Cancer Foundation
- EC
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Caspase-2, the most conserved member of the caspase family, has long been recognized as an important protein in the regulation of apoptosis. However, due to a lack of phenotype in caspase-2 knock-out mice, its precise role has been questioned. Recently, several publications have described new mechanisms regulating caspase-2 activation, including its role within an activating complex named the PIDDosome, linking caspase-2 function to p53. Consistent with this, evidence is accumulating for potential roles of caspase-2 in non-apoptotic processes, including cell cycle regulation and DNA repair. In addition, a tumor-suppressor function has been suggested for caspase-2. Here we discuss how different PIDDosome complexes could be involved in mechanisms regulating the switch between the various functions of caspase-2.
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