Journal
TRENDS IN CELL BIOLOGY
Volume 19, Issue 1, Pages 16-23Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.10.003
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Funding
- NATIONAL CANCER INSTITUTE [ZIABC010329] Funding Source: NIH RePORTER
- Intramural NIH HHS [ZIA BC010329-11] Funding Source: Medline
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The highly conserved 14-3-3 protein family has risen to a position of importance in cell biology owing to its involvement in vital cellular processes, such as metabolism, protein trafficking, signal transduction, apoptosis and cell-cycle regulation. The 14-3-3 proteins are phosphoserine/phospho-threonine binding proteins that interact with a diverse array of binding partners. Because many 14-3-3 interactions are phosphorylation-dependent, 14-3-3 has been tightly integrated into the core phosphoregulatory pathways that are crucial for normal growth and development and that often become dysregulated in human disease states such as cancer. This review examines the recent advances that further elucidate the role of 14-3-3 proteins as integrators of diverse signaling cues that influence cell fate decisions and tumorigenesis.
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