Journal
TRENDS IN CELL BIOLOGY
Volume 19, Issue 3, Pages 119-129Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.01.003
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Funding
- Grants-in-Aid for Scientific Research
- Ministry of Education, Science and Culture, Japan
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Wnts comprise a large family of secreted, hydrophobic glycoproteins that control a variety of developmental and adult processes in all metazoan organisms, including cellular proliferation, differentiation, migration and polarity. Writs have many receptors that are present on a variety of cell types, partly specifying which Wnt pathways are activated. Recently, evidence has been accumulating that specificity of activation downstream of Wnt is also regulated by receptor-mediated endocytosis and the presence of cofactors such as heparan sulfate proteoglycans, in addition to the formation of specific ligand-receptor pairs. Here, we describe how the different endocytic routes of Wnt receptors through caveolin and clathrin determine specificity of Wnt signaling in vertebrates.
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