Journal
TRENDS IN CELL BIOLOGY
Volume 19, Issue 5, Pages 198-206Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.02.006
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Funding
- NIH [RO1 CA113733, RO1 NS034738]
- DOD [W81XWH-05-1-0189]
- NATIONAL CANCER INSTITUTE [R01CA113733] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS034783] Funding Source: NIH RePORTER
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Recent studies highlight the importance of the distribution of membrane receptors in controlling receptor output and in contributing to complex biological processes. The cortical cytoskeleton is known to affect membrane protein distribution but the molecular basis of this is largely unknown. Here, we discuss the functions of Merlin and the ERM proteins both in linking membrane proteins to the underlying cortical cytoskeleton and in controlling the distribution of and signaling from membrane receptors. We also propose a model that could account for the intricacies of Merlin function across model organisms.
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