Journal
TRENDS IN CELL BIOLOGY
Volume 19, Issue 5, Pages 189-197Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.02.003
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Funding
- AMN
- Universite Diderot-Paris VII fellowship
- INSERM
- CNRS
- Institut Universitaire de France
- Association pour la Recherche contre le Cancer (ARC)
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Cellular responses to environmental or physiological cues rely on transduction pathways that must ensure discrimination between different signals. These cascades 'crosstalk' and lead to a combinatorial regulation. This often results in different combinations of post-translational modifications (PTMs) on target proteins, which might act as a molecular barcode. Although appealing, the idea of the existence of such a code for transcription factors is debated. Using general arguments and recent evidence, we propose that a PTM code is not only possible but necessary in the context of transcription factors regulating multiple processes. Thus, the coding potential of PTM combinations should both provide a further layer of information integration from several transduction pathways and warrant highly specific cellular outputs.
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