Journal
TRENDS IN CELL BIOLOGY
Volume 19, Issue 1, Pages 24-28Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.11.001
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Funding
- NIGMS NIH HHS [R37 GM045443] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R37GM045443] Funding Source: NIH RePORTER
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Development requires the translation of stored maternal messenger RNAs (mRNAs) in a spatial and temporally specified manner. Maternal mRNAs are often in large RNA-protein (RNP) granules. Recent papers reveal that maternal mRNA granules in Caenorhabditis elegans oocytes and early development are dynamic and related to P-bodies and stress granules, which are conserved RNP granules seen in somatic cells. In addition, a highly conserved putative RNA helicase, termed CGH-1 in C. elegans, is now shown to be important for both for translation repression and the stability of stored mRNAs. The analysis of CGH-1 ortholog functions in somatic cells and its interacting proteins indicate possible mechanisms by which this protein family might stabilize stored maternal mRNAs.
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