Journal
TRENDS IN CELL BIOLOGY
Volume 19, Issue 12, Pages 669-676Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2009.08.006
Keywords
-
Categories
Funding
- Netherlands Organization for Scientific Research (NWO-ALW/ECHO)
- Netherlands Organization for Health Research and Development (ZonMw-VIDVrOP)
- European Science Foundation [European Young Investigators (EURYI) Award]
- Human Frontier Science Program Career Development Award (EFSP-CDA)
- Deutsche Forschungsgemeinschaft (DFG)
- Human Frontier Science Program Career Development Award (HFSP-CDA)
- International Foundation for Research in Paraplegia (IRP)
Ask authors/readers for more resources
Microtubules have been regarded as essential structures for stable neuronal morphology but new studies are highlighting their role in dynamic neuronal processes. Recent work demonstrates that the microtubule cytoskeleton has an active role during different phases of neuronal polarization - microtubules and their stability determine axon formation, they maintain the identity of axons and they regulate the dynamics of dendritic spines, the major sites of excitatory synaptic input. Although microtubules fulfill distinct cellular functions at different developmental stages, the underlying molecular mechanisms are remarkably similar. Reccurring themes are that microtubules direct specific membrane traffic and affect actin dynamics to locally organize axon growth and spine dynamics. We review the novel role of microtubules during neuronal development and discuss models for microtubule-dependent signaling in neuronal plasticity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available