Journal
TRENDS IN CELL BIOLOGY
Volume 18, Issue 8, Pages 357-359Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.05.005
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Funding
- Spanish Ministry of Education and Science [BFU2005-05772, SAF2007-63051, NAN2004-09230-C04, CSD2007-00017]
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Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.
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