Journal
TRENDS IN CELL BIOLOGY
Volume 18, Issue 7, Pages 307-310Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.05.003
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Funding
- NIGMS NIH HHS [R01 GM032238-22, R01 GM032238] Funding Source: Medline
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Recent studies suggest that the human Kinesin-8 molecular motor Kif18A has a role in chromosome congression. Specifically, these studies find that Kif18A promotes chromosome congression by attenuating chromosome oscillation magnitudes. Together with recent modeling work, in vitro studies, and the analysis of in vivo yeast data, these reports reveal how Kinesin-8 molecular motors might control chromosome oscillation amplitudes by spatially regulating the dynamic instability of microtubule plus-ends within the mitotic spindle.
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