Journal
TRENDS IN CELL BIOLOGY
Volume 18, Issue 10, Pages 474-485Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.08.002
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Funding
- NIH [GM067848]
- Cancer Research Institute
- Rita Allen Foundation
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067848] Funding Source: NIH RePORTER
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In metazoan organisms, cells undergoing apoptosis are rapidly engulfed and degraded by phagocytes. Defects in apoptotic-cell clearance result in inflammatory and autoimmune responses. However, little is known about how apoptotic-cell degradation is initiated and regulated and how different phagocytic targets induce different immune responses from their phagocytes. Recent studies in mammalian systems and invertebrate model organisms have led to major progress in identifying new factors involved in the maturation of phagosomes containing apoptotic cells. These studies have delineated signaling pathways that promote the sequential incorporation of intracellular organelles to phagosomes and have also discovered that phagocytic receptors produce the signals that initiate phagosome maturation. Here, we discuss these exciting new findings, focusing on the mechanisms that regulate the interactions between intracellular organelles and phagosomes.
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