Journal
TRENDS IN CELL BIOLOGY
Volume 18, Issue 10, Pages 451-455Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.07.006
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The DNA-damage response (DDR) is an evolutionarily conserved signaling cascade crucial for sensing DNA damage and activating cellular responses such as cell-cycle arrest, DNA repair, senescence and apoptosis. Excitingly, two recent studies describe activation of this checkpoint in the absence of DNA damage. These studies support the idea that accumulation of checkpoint proteins and changes in global-chromatin structure are important signaling intermediates for the activation of the DDR.
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