Journal
TRENDS IN CELL BIOLOGY
Volume 18, Issue 8, Pages 360-363Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcb.2008.06.001
Keywords
-
Categories
Funding
- E.U.
- Medical Research Council (MRC)
- MRC
- MRC [MC_U117584268] Funding Source: UKRI
- Medical Research Council [MC_U117584268] Funding Source: researchfish
Ask authors/readers for more resources
Glypicans are glycosylphosphatidylinositol-linked heparan sulfate proteoglycans that play an essential part in the regulation of morphogen signalling. Two new reports using Drosophila and mice have highlighted the importance of glypican endocytosis in the regulation of Hedgehog (Hh) signalling and in Wingless gradient formation. One Drosophila glypican, Daily-like, acts positively in Hh signalling, whereas mouse Glypican-3 is a negative regulator. This difference seems to be dependent on whether glypicans promote the internalization of Hh alone or as a complex with its receptor, Patched.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available