Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 24, Issue 6, Pages 256-262Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2014.05.010
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Funding
- National Institutes of Health, USA [1R01HL105759, 1R37HL091102, 5R01HL067245, 1R01HL117163, 1R01HL113647, 2P01HL085577]
- American Heart Association, USA [12POST12060191]
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Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a molecular orchestrator of a myriad of signal transduction pathways in the heart. (C) 2014 Elsevier Inc. All rights reserved.
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