Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 24, Issue 1, Pages 7-13Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2013.05.003
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Funding
- University Medical Center Gottingen
- DZHK (German Center for Cardiovascular Research)
- German Federal Ministry for Science and Education [BMBF FKZ 01GN0827, FKZ 01GN0957]
- German Research Foundation [DFG ZI 708/7-1, 8-1, 10-1, SFB 1002]
- European Union FP7 CARE-MI
- CIRM/BMBF FKZ [13GW0007A]
- NIH [U01 HL099997]
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The introduction of biomimetic culture paradigms has advanced myocardial tissue engineering fundamentally, enabling today the provision of engineered rodent and human heart muscle with features characteristically found in postnatal myocardium. This is in marked contrasts to flat cardiomyocyte cultures with their typically low degree of organotypic maturation. Here, we discuss the collagen hydrogel-based engineered heart muscle (EHM) technology and provide background information on its use in simulations of myocardial growth and disease. (C) 2013 Elsevier Inc. All rights reserved.
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