The impact of microRNAs on the regulation of tissue factor biology

Tissue factor (TF) and its isoforms play an important role in a variety of physiologic and pathophysiologic functions, such as initiation of blood coagulation, vessel wall hemostasis, angiogenesis, and tumorigenesis. Micro(mi)RNAs are crucial for post-transcriptional control of protein generation by regulating the expression of one-third of all human genes. In recent years, miRNAs were shown to modulate the expression and biologic function of TF in different physiologic- and pathophysiologic-relevant settings, such as in autoimmune diseases and in different types of cancer. In the present review, we will summarize and discuss the latest findings regarding the impact of miRNAs on the generation of TF and its isoforms as well as on regulation of TF biology under normal and pathophysiologic conditions. (C) 2013 Elsevier Inc. All rights reserved.