Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 22, Issue 8, Pages 197-201Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2012.07.020
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Fetuin-A is a liver-derived plasma protein involved in calcified matrix metabolism. Fetuin-A mediates the formation and stabilization of calciprotein particles (CPPs), soluble colloids made of fetuin-A, further serum proteins, and calcium phosphate mineral. CPP formation ensures mineral solubilization and rapid clearance from circulation by macrophages of the mononuclear phagocyte system, thus preventing pathological calcification. Accordingly, low levels of free serum fetuin-A and high serum CPPs are associated with pathological calcification in patients suffering from chronic kidney disease. (Trends Cardiovasc Med 2012;22:197-201) (C) 2012 Elsevier Inc. All rights reserved.
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