Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 19, Issue 6, Pages 179-182Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2009.11.001
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Funding
- Takeda Science Foundation
- Japan Society for the Promotion of Science
- Sumitomo Foundation
- Mitsubishi Pharma Research Foundation
- National Institutes of Health [HL54737]
- Packard Foundation
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Seryl-transfer RNA synthetase (Sars) is one of the 20 aminoacyl-transfer RNA synthetases that are enzymes essential for protein synthesis; however, the developmental function of Sars has not been elucidated. In zebrafish, impairment of zygotic Sars function leads to a significant dilatation of the aortic arch vessels and aberrant branching of cranial and intersegmental vessels. This abnormal vascular branching in sars mutants can be suppressed by a form of Sars that lacks canonical function, indicating that a noncanonical activity of Sars regulates vascular development. Inhibition or knockdown of vascular endothelial growth factor (Vegf) signaling, which plays pivotal roles in the establishment of the vascular network, suppresses the abnormal vascular branching observed in sars mutants. Here, we discuss the possible functional relationship between Sars function and Vegf signaling. (Trends Cardiovasc Med 2009;19:179-182) (C) 2009, Elsevier Inc.
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