Journal
TRENDS IN CARDIOVASCULAR MEDICINE
Volume 19, Issue 3, Pages 103-107Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tcm.2009.06.004
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL042397] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL042397-18] Funding Source: Medline
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Hemoglobin-based oxygen carriers (HBOCs) have been studied for decades as red blood cell substitutes. Profound vasoconstrictor effects have limited the clinical utility of HBOCs and are attributable to avid scavenging of nitric oxide (NO). Inhaling NO can charge the body's stores of NO metabolites without producing hypotension and can prevent systemic hypertension induced when HBOCs are subsequently infused. Concurrent breathing of low NO doses can prevent pulmonary vasoconstriction after HBOC infusion without augmenting plasma methemoglobinemia. (Trends Cardiovasc Med 2009; 19:103-107) (C) 2009, Elsevier Inc.
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