Journal
TRENDS IN BIOTECHNOLOGY
Volume 32, Issue 6, Pages 297-303Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.03.009
Keywords
endophytic fungi; red biotechnology; plant-microbe interaction; endophyte biotechnology; industrial bioprocess; synthetic biology; secondary metabolites; biosynthetic pathway
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Funding
- International Bureau (IB) of the German Federal Ministry of Education and Research (BMBF/DLR), Germany
- Ministry of Innovation, Science, Research, and Technology of the State of North Rhine-Westphalia, Germany
- German Academic Exchange Service (DAAD
- Welcome to Africa' initiative)
- German Research Foundation (Deutsche Forschungsgemeinschaft, DFG)
- Department of Biotechnology (DBT)
- India and the Council of Scientific and Industrial Research (CSIR), India
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The potential of endophytes, particularly endophytic fungi, capable of demonstrating desirable functional traits worth exploitation using red biotechnology is well established. However, these discoveries have not yet translated into industrial bioprocesses for commercial production of biopharmaceuticals using fungal endophytes. Here, we define the current challenges in transforming curiosity driven discoveries into industrial scale endophyte biotechnology. The possible practical, feasible, and sustainable strategies that can lead to harnessing fungal endophyte-mediated pharmaceutical products are discussed.
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