Journal
TRENDS IN BIOTECHNOLOGY
Volume 32, Issue 9, Pages 483-492Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.06.008
Keywords
chemokines; in situ tissue engineering; mesenchymal stem cells; regenerative medicine; mobilization and homing; CCL25
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Funding
- Federal Ministry of Education and Research (BMBF) [1315848A]
- European Development Fund (IBB/EFRE) [10147246]
- German Research Foundation (DFG) [SI 569/7-1]
- Investitionsbank Berlin
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Chemokines are potent stem cell homing and mobilization factors, and artificially increasing the concentrations of specific chemokines at injury sites is an up-to-date strategy to potentiate and prolong the recruitment of endogenous stem cells and to amplify in situ tissue regeneration. We briefly outline the latest progress in stem cell recruitment focusing on the interactions of mesenchymal stem cells (MSCs) with chemokines, complement cascade peptides, bioactive lipids, and glycosaminoglycans (GAGs). We present recent advances in state-of-the-art chemokine delivery devices suitable for various applications and critically evaluate the perspectives and challenges of the chemokine-guided in situ strategy for translation in regenerative medicine.
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