Journal
TRENDS IN BIOTECHNOLOGY
Volume 32, Issue 6, Pages 337-343Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.04.003
Keywords
cofactor systems; cofactor engineering; redox balance; synthetic biology.
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Funding
- Major State Basic Research Development Program of China [2013CB733602]
- National Natural Science Foundation of China [31270079]
- Program for Young Talents in China
- Provincial Outstanding Youth Foundation of Jiangsu Province [BK2012002]
- Program for Innovative Research Team in University [IRT1249]
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Redox balance plays an important role in the production of enzymes, pharmaceuticals, and chemicals. To meet the demands of industrial production, it is desirable that microbes maintain a maximal carbon flux towards target metabolites with no fluctuations in redox. This requires functional cofactor systems that support dynamic homeostasis between different redox states or functional stability in a given redox state. Redox balance can be achieved by improving the self-balance of a cofactor system, regulating the substrate balance of a cofactor system, and engineering the synthetic balance of a cofactor system. This review summarizes how cofactor systems can be manipulated to improve redox balance in microbes.
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