Journal
TRENDS IN BIOTECHNOLOGY
Volume 32, Issue 10, Pages 538-548Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.08.003
Keywords
breathomics; volatile organic compounds; personalized medicine; point-of-care; eNose; mass spectrometry
Categories
Funding
- UK Medical Research Council (MRC)
- UK Biotechnology and Biological Sciences Research Council (BBSRC)
- Cancer Research UK (CRUX)
- Biotechnology and Biological Sciences Research Council [BB/C519038/1] Funding Source: researchfish
- Medical Research Council [MC_qA137293] Funding Source: researchfish
- MRC [MC_qA137293] Funding Source: UKRI
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Breath-based metabolomics (breathomics) is an exciting developing area of biotechnology that centers on the capture, identification, and quantification of volatile organic compound (VOC) patterns in human breath and their utilization as tools in the diagnosis of a broad spectrum of medical problems. With the age of personalized medicines demanding rapid bespoke diagnosis and treatment, this area of molecular diagnostics is beginning to see an upsurge in biotechnological advancement. Here, we discuss recent improvements and directions in the development of breath VOC analysis and diagnosis platforms that offer the potential for disease biomarker discovery and disease prognosis.
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