Journal
TRENDS IN BIOTECHNOLOGY
Volume 32, Issue 2, Pages 74-81Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2013.12.002
Keywords
tissue regeneration; regenerative engineering; musculoskeletal tissue; small molecules
Categories
Funding
- NIH [R21-AR060480]
- Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences
- State of Connecticut Stem Cell Research Foundation
- Presidential Award for Excellence in Science, Mathematics, and Engineering Mentorship from President Barack Obama
- Directorate For Engineering
- Emerging Frontiers & Multidisciplinary Activities [1332329] Funding Source: National Science Foundation
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Clinicians and scientists working in the field of regenerative engineering are actively investigating a wide range of methods to promote musculoskeletal tissue regeneration. Small-molecule-mediated tissue regeneration is emerging as a promising strategy for regenerating various musculoskeletal tissues and a large number of small-molecule compounds have been recently discovered as potential bioactive molecules for musculoskeletal tissue repair and regeneration. In this review, we summarize the recent literature encompassing the past 4 years in the area of small bioactive molecules for promoting repair and regeneration of various musculoskeletal tissues including bone, muscle, cartilage, tendon, and nerve.
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