Journal
TRENDS IN BIOTECHNOLOGY
Volume 31, Issue 1, Pages 45-51Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2012.10.012
Keywords
peptide microarray; immunodiagnostics; antibody profiling; biomarker discovery; health monitoring
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Health is a complex interaction between metabolism, physiology, and immunity. Although it is difficult to define quantitatively, the activity of the humoral immune system provides a reasonable proxy for changes in health. Immunosignaturing is a microarray-based technology that quantitates the dynamics of circulating antibodies. Recent advancements in the field warrant a review of the technology. Here, we provide an introduction to the technique, evaluate the current progress, contrast similar technologies, and suggest applications that immunosignaturing could facilitate.
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