Journal
TRENDS IN BIOTECHNOLOGY
Volume 30, Issue 3, Pages 138-146Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2011.06.013
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Funding
- National Institutes of Health (NIH), part of the NIH Roadmap for Medical Research [1-DP2-OD004346-01]
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Because the native cellular environment is 3D, there is a need to extend planar, micro- and nanostructured biomedical devices to the third dimension. Self-folding methods can extend the precision of planar lithographic patterning into the third dimension and create reconfigurable structures that fold or unfold in response to specific environmental cues. Here, we review the use of hinge-based self-folding methods in the creation of functional 3D biomedical devices including precisely patterned nano- to centimeter scale polyhedral containers, scaffolds for cell culture and reconfigurable surgical tools such as grippers that respond autonomously to specific chemicals.
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