Journal
TRENDS IN BIOTECHNOLOGY
Volume 30, Issue 10, Pages 528-537Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2012.07.001
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Funding
- European Community [PIEF-GA-2009-252558]
- National Science Fund of Bulgaria [DO-02-261/2008]
- EPSCoR
- Office Of The Director [1003970] Funding Source: National Science Foundation
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Hairy root syndrome is a disease that is induced by Agrobacterium rhizogenes infection and characterized by a proliferation of excessively branching roots. However, in the past 30 years A. rhizogenes-mediated transformation has also provided a valuable platform for studying biosynthesis pathways in plants. Furthermore, the genetically transformed root cultures are becoming increasingly attractive, cost-effective options for mass-producing desired plant metabolites and expressing foreign proteins. Numerous proof-of-concept studies have demonstrated the feasibility of scaling up hairy-root-based processes while maintaining their biosynthetic potential. Recently, hairy roots have also shown immense potential for applications in phytoremediation, that is, plant-based decontamination of polluted environments. This review highlights recent progress and limitations in the field, and outlines future perspectives for the industrial exploitation of hairy roots.
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