Journal
TRENDS IN BIOTECHNOLOGY
Volume 29, Issue 8, Pages 379-387Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2011.03.004
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Funding
- Natural Sciences and Engineering Research Council
- Canadian Institutes of Health Research
- US National Institutes of Health [EB006903]
- Ontario Graduate Scholarship Program
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Rebuilding tissues involves the creation of a vasculature to supply nutrients and this in turn means that the endothelial cells (ECs) of the resulting endothelium must be a quiescent non-thrombogenic blood contacting surface. Such ECs are deployed on biomaterials that are composed of natural materials such as extracellular matrix proteins or synthetic polymers in the form of vascular grafts or tissue-engineered constructs. Because EC function is influenced by their origin, biomaterial surface chemistry and hemodynamics, these issues must be considered to optimize implant performance. In this review, we examine the recent in vivo use of endothelialized biomaterials and discuss the fundamental issues that must be considered when engineering functional vasculature.
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