Journal
TRENDS IN BIOTECHNOLOGY
Volume 29, Issue 7, Pages 307-313Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2011.02.006
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Funding
- NSF [CBET0755775]
- EPA [R833008]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1129012] Funding Source: National Science Foundation
- EPA [909166, R833008] Funding Source: Federal RePORTER
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Traditional methods that rely on viral isolation and culture techniques continue to be the gold standards used for detection of infectious viral particles. However, new techniques that rely on visualization of live cells can shed light on understanding virus host interaction for early stage detection and potential drug discovery. Live-cell imaging techniques that incorporate fluorescent probes into viral components provide opportunities for understanding mRNA expression, interaction, and virus movement and localization. Other viral replication events inside a host cell can be exploited for non-invasive detection, such as single-virus tracking, which does not inhibit viral infectivity or cellular function. This review highlights some of the recent advances made using these novel approaches for visualization of viral entry and replication in live cells.
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