Journal
TRENDS IN BIOTECHNOLOGY
Volume 29, Issue 8, Pages 370-378Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2011.04.001
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Funding
- Advanced Biomass R&D Center of Korea through the Global Frontier Research Program of the Ministry of Education, Science and Technology (MEST) [ABC-2010-0029799, R32-2008-000-10142-0]
- GS Caltex
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Metabolic engineering has contributed significantly to the enhanced production of various value-added and commodity chemicals and materials from renewable resources in the past two decades. Recently, metabolic engineering has been upgraded to the systems level (thus, systems metabolic engineering) by the integrated use of global technologies of systems biology, fine design capabilities of synthetic biology, and rational random mutagenesis through evolutionary engineering. By systems metabolic engineering, production of natural and unnatural chemicals and materials can be better optimized in a multiplexed way on a genome scale, with reduced time and effort. Here, we review the recent trends in systems metabolic engineering for the production of chemicals and materials by presenting general strategies and showcasing representative examples.
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