Journal
TRENDS IN BIOTECHNOLOGY
Volume 28, Issue 7, Pages 363-370Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2010.04.002
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Funding
- NWO middelgroot [40-00506-90-0602]
- EU [HEALTH-F5-2008-201842, LSHC-CT-2006- 518234]
- National Institutes of Health [R01-CA134633, R01-EB003453, P01-HD047675, P41-EB001977]
- Dana Foundation
- NWO Vidi [917.76.363]
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Cellular therapy, including stem cell transplants and dendritic cell vaccines, is typically monitored for dosage optimization, accurate delivery, and localization using noninvasive imaging, of which magnetic resonance imaging (MRI) is a key modality. F-19 MRI retains the advantages of MRI as an imaging modality, and also allows direct detection of labeled cells for unambiguous identification and quantification, unlike typical metal-based contrast agents. Recent developments in F-19 MRI-based in vivo cell quantification, the existing clinical use of F-19 compounds and current explosive interest in cellular therapeutics have brought F-19 imaging technology closer to clinical application. We review the application of F-19 MRI to cell tracking, discussing intracellular F-19 labels, cell labeling and in vivo quantification, as well as the potential clinical uses of F-19 MRI.
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