Journal
TRENDS IN BIOTECHNOLOGY
Volume 27, Issue 12, Pages 664-672Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2009.08.006
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Funding
- National Natural Science Foundation of China [30870040]
- National Basic Research Program of China (973 Project) [2007CB707803, 2007CB714301]
- National High Technology Research and Development Program of China (863 Project) [2006AA020103, 2006AA02Z237]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KSCX2-YW-G-005, KSCX2-YW-G007, KSCX1-YW-11C3]
- Hundred Talents Program of the Chinese Academy of Sciences
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Good physiological performance of industrial microbes is crucial for successful bioprocesses. Conventional metabolism-oriented engineering strategies often fail to obtain expected phenotypes owing to focusing narrowly on targeted metabolic capabilities while neglecting microbial physiological responses to environmental stresses. To meet the new challenges posed by the biotechnological production of fuels, chemicals and materials, microbes should exert strong physiological robustness and fitness, in addition to strong metabolic capabilities, to enable them to work efficiently in actual bioprocesses. Here, we address the importance of engineering physiological functionalities into microbes and illustrate the operation procedure. We believe that this physiology-oriented engineering strategy is a promising approach for improving the physiological performance of industrial microbes for efficient bioprocesses.
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