Journal
TRENDS IN BIOTECHNOLOGY
Volume 26, Issue 12, Pages 674-681Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2008.08.003
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Funding
- National Science Foundation [0540879]
- MIT Energy Initiative [6917278]
- Directorate For Engineering [0540879] Funding Source: National Science Foundation
- Div Of Engineering Education and Centers [0540879] Funding Source: National Science Foundation
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Typically, the outcome of biologically engineered unit operations cannot be controlled a priori due to the incorporation of ad hoc design into complex natural systems. To mitigate this problem, synthetic biology presents a systematic approach to standardizing biological components for the purpose of increasing their programmability and robustness when assembled with the aim to achieve novel biological functions. A complex engineered biological system using only standardized biological components is yet to exist. Nevertheless, current attempts to create and to implement modular, standardized biological components pave the way for the future creation of highly predictable artificial biological systems. Although synthetic biology frameworks can be applied to any biological engineering endeavor, this article will focus on providing a brief overview of advances in the field and its recent utilization for the engineering of microbes.
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