Journal
TRENDS IN BIOTECHNOLOGY
Volume 26, Issue 7, Pages 382-392Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2008.03.011
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Funding
- NHLBI NIH HHS [R01 HL069957] Funding Source: Medline
- NIDCR NIH HHS [R37 DE0133033, R01 DE013349] Funding Source: Medline
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One goal of tissue engineering is to replace lost or compromised tissue function, and an approach to this is to control the interplay between materials (scaffolds), cells and growth factors to create environments that promote the regeneration of functional tissues and organs. An increased understanding of the chemical signals that direct cell differentiation, migration and proliferation, advances in scaffold design and peptide engineering that allow this signaling to be recapitulated and the development of new materials, such as DNA-based and stimuli-sensitive polymers, have recently given engineers enhanced control over the chemical properties of a material and cell fate. Additionally, the immune system, which is often overlooked, has been shown to play a beneficial role in tissue repair, and future endeavors in material design will potentially expand to include immunomodulation.
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