Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 9, Pages 381-399Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.07.002
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Funding
- National Institutes of Health [R01GM106056, U01GM103804, R01HG003008]
- National Science Foundation [MCB-1413539]
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1413539] Funding Source: National Science Foundation
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Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a genome. TFs recognize DNA in a specific manner; the mechanisms underlying this specificity have been identified for many TFs based on 3D structures of protein DNA complexes. More recently, structural views have been complemented with data from high-throughput in vitro and in vivo explorations of the DNA-binding preferences of many TFs. Together, these approaches have greatly expanded our understanding of TF-DNA interactions. However, the mechanisms by which TFs select in vivo binding sites and alter gene expression remain unclear. Recent work has highlighted the many variables that influence TF-DNA binding, while demonstrating that a biophysical understanding of these many factors will be central to understanding TF-function.
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