Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 6, Pages 257-259Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.04.006
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Funding
- NICHD NIH HHS [R00 HD057233, HD057233, K99 HD057233] Funding Source: Medline
- NIGMS NIH HHS [R01 GM097363, GM097363] Funding Source: Medline
- NIH HHS [OD007371A, DP2 OD007371] Funding Source: Medline
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Argonaute proteins are central players in small RNA-mediated silencing mechanisms such as RNA interference (RNAi), microRNA repression and piRNA-mediated transposon silencing. In eukaryotes, Argonautes bind small RNAs that guide them to RNA targets in order to regulate gene expression and repress invasive genomic elements. Although Argonaute proteins are conserved in all life forms from bacteria to eukaryotes, until now studies have focused on the biological functions of eukaryotic Argonautes. Here we highlight two recent studies that discover the functions of prokaryotic Argonautes in defence against exogenous DNA.
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