Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 3, Pages 112-120Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.12.007
Keywords
cancer; selenium; selenocysteine; selenoproteins
Categories
Funding
- Intramural Research Program of the National Institutes of Health (NIH)
- National Cancer Institute
- Center for Cancer Research
- NIH
Ask authors/readers for more resources
The many biological and biomedical effects of selenium are relatively unknown outside the selenium field. This fascinating element, initially described as a toxin, was subsequently shown to be essential for health and development. By the mid-1990s selenium emerged as one of the most promising cancer chemopreventive agents, but subsequent human clinical trials yielded contradictory results. However, basic research on selenium continued to move at a rapid pace, elucidating its many roles in health, development, and in cancer prevention and promotion. Dietary selenium acts principally through selenoproteins, most of which are oxidoreductases involved in diverse cellular functions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available