Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 6, Pages 289-298Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.04.003
Keywords
PRDM14; pluripotency; pluripotent stem cells; primordial germ cells; epigenetic reprogramming; global DNA demethylation
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PRDM14 belongs to the PR domain-containing (PRDM) transcriptional regulators. Among the PRDM family members, PRDM14 shows specific expression in preimplantation embryos, primordial germ cells (PGCs), and embryonic stem cells (ESCs) in vitro, and accordingly plays a key role in the regulation of their pluripotency and epigenetic reprogramming, most notably, genome-wide DNA demethylation. The function of PRDM14 appears to be conserved between mice and humans, but it shows several characteristic differences between the two species. A precise understanding of the function of PRDM14 in mice and humans would shed new light on the regulation of pluripotency and the epigenome in these two species, providing a foundation for better control of stem cell fates in a broader context.
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