Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 12, Pages 603-611Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.09.004
Keywords
phospholipase C; disease-linked mutations; immune disorders; cancer; deregulation of signaling
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Funding
- Cancer Research UK
- Wellcome Trust
- Cancer Research UK [16567] Funding Source: researchfish
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The surge in genetic and genomic investigations over the past 5 years has resulted in many discoveries of causative variants relevant to disease pathophysiology. Although phospholipase C (PLC) enzymes have long been recognized as important components in intracellular signal transmission, it is only recently that this approach highlighted their role in disease development through gain-of-function mutations. In this review we describe the new findings that link the PLC gamma family to immune disorders and cancer, and illustrate further efforts to elucidate the molecular mechanisms that underpin their dysfunction.
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