Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 10, Pages 496-503Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.08.003
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Funding
- National Institutes of Health [GM046383, GM107615]
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Quantitative studies of signal transduction systems have shown that ultrasensitive responses switch-like, sigmoidal input/output relationships are commonplace in cell signaling. Ultrasensitivity is important for various complex signaling systems, including signaling cascades, bistable switches, and oscillators. In this first installment of a series on ultrasensitivity we survey the occurrence of ultrasensitive responses in signaling systems. We review why the simplest mass action systems exhibit Michaelian responses, and then move on to zero-order ultrasensitivity, a phenomenon that occurs when signaling proteins are operating near saturation. We also discuss the physiological relevance of zero-order ultrasensitivity to cellular regulation.
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