Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 39, Issue 4, Pages 159-169Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2014.02.003
Keywords
FOXO transcription factors; cellular quality control; aging; proteostasis
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Funding
- National Institutes of Health (NIH) [P01 AG036695]
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FOXO transcription factors are conserved regulators of longevity downstream of insulin signaling. These transcription factors integrate signals emanating from nutrient deprivation and stress stimuli to coordinate programs of genes involved in cellular metabolism and resistance to oxidative stress. Here, we discuss emerging evidence for a pivotal role of FOXO factors in promoting the expression of genes involved in autophagy and the ubiquitin-proteasome system - two cell clearance processes that are essential for maintaining organelle and protein homeostasis (proteostasis). The ability of FOXO to maintain cellular quality control appears to be critical in processes and pathologies where damaged proteins and organelles accumulate, including aging and neurodegenerative diseases.
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