Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 38, Issue 10, Pages 494-506Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.07.004
Keywords
stress granules; translation; cell signaling; protein aggregation; intrinsically disordered
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Funding
- NCI NIH HHS [R01 CA168872] Funding Source: Medline
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Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors, and specific RNA-binding proteins. In addition many signaling proteins are recruited to SGs and/or influence their assembly, which is transient, lasting only until the cells adapt to stress or die. Beyond their role as mRNA triage centers, we posit that SGs constitute RNA-centric signaling hubs analogous to classical multiprotein signaling domains such as transmembrane receptor complexes. As signaling centers, SG formation communicates a 'state of emergency', and their transient existence alters multiple signaling pathways by intercepting and sequestering signaling components. SG assembly and downstream signaling functions may require a cytosolic phase transition facilitated by intrinsically disordered, aggregation-prone protein regions shared by RNA-binding and signaling proteins.
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